Warfarin Pharmacomicrobiomics

Warfarin pharmacogenomics has been on my mind for quite awhile. Warfarin acts as an anticoagulant by inhibiting the vitamin K cycle which is responsible for creating blood clotting factors. When I learned that vitamin K was produced by bacteria in the gut microbiome, I hypothesized that vitamin K producing capability of the gut microbiome would be associated with warfarin dose requirements.


Qiime My sequencing was done by Ion Torrent which made Qiime a bit difficult to use because of lacking documentation. I followed, mostly, this post by Carli Jones: https://forum.qiime2.org/t/possible-analysis-pipeline-for-ion-torrent-16s-metagenomics-kit-data-in-qiime2/13476.